MetaboNews June: Matej Orešič

Prof. Matej Orešič and His Research in Metabolomics

Matej Orešič is a professor of medicine (systems medicine) at Örebro University in Sweden and a professor of biochemistry (metabolomics) at the University of Turku in Finland. His research primarily focuses on exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in identifying environmental exposures (exposome) and disease processes linked to different metabolic phenotypes and understanding the mechanisms connecting these processes to the development of specific disorders or their co-morbidities.

Prof. Orešič initiated the MZmine open-source project, which led to the creation and release of widely-used software for metabolomics data processing. He serves on the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, where he previously served as chair of the board. Within the Metabolomics Society, he chairs the International Affiliates Task Group and co-founded and serves as secretary of the Lipidomics Task Group (LipidMet).

Professor Orešič currently also coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course healthINITIALISE”. He is also Vice-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver diseaseEDC-MASLD”.

Metabolomics, Exposomics, and Lipidomics

In the interview, he highlights the significant diversity within the Metabolomics community and the numerous unknowns still to be uncovered as two of the field’s greatest strengths. He also briefly touches on exposomics and lipidomics.

Exposomics is quickly growing and plays a crucial role in understanding human health. Applying these technologies in toxicology can aid in creating models for mixed toxins, studying the interactions between chemical toxicants and stressors, and integrating information into adverse outcome pathways (AOPs) for both emerging and known toxins. Recently, TMIC summarized an article to explore the complex relationship between environmental factors and human health, Exploring the World of Exposomics: Understanding Environmental Impacts on Health. Some of the quantitative exposomics assays:

TMIC has also curated a collection of resources focusing on lipidomics, providing deeper insights into lipidomics analysis. Explore the following trio of articles for a comprehensive examination of the subject:

  1. Lipidomics Analysis: This article offers an overview of lipidomics, covering its emergence, methodologies, differences from metabolomics, types of analysis (global vs. targeted), measurable components, lipid classes, and common sample types. It provides an intricate look into lipidomics analysis.
  2. Lipidomics for Studying Metabolism: This article discusses the utility of lipidomics in studying metabolism, emphasizing its role in characterizing lipid profiles, understanding metabolic pathways, identifying disease biomarkers, aiding drug development, and integrating with other omics data for a comprehensive analysis of cellular processes. It also includes publications related to targeted and untargeted lipidomics analyses.
  3. Extracellular vesicles (EVs) 101: This article covers the basics of extracellular vesicles (EVs) and their significance in lipidomics research. It explores the fundamentals of EVs and their potential as biomarkers, particularly in cancer detection.
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