Multiplexed LC–ESI–MRM‐MS‐based Assay for Identification of Coronary Artery Disease Biomarkers in Human Plasma

Featured on the back cover of Proteomics – Clinical Applications, Dr. Christoph Borchers’ newest publication focuses on the identification of biomarkers specific to coronary artery disease (CAD). Along with a group of BC scientists, including researchers from the University of Victoria and University of British Columbia, Dr. Borchers helped develop an LC-ESI-MS based assay that can measure 107 stable isotope labeled peptide standards and native peptides in tryptic digests of plasma.

After extensive computational and statistical analysis of samples from subjects with and without angiographic evidence of CAD, the assay revealed six plasma proteins associated with the disease. If the results of the study are externally validated, the assay and identified biomarkers can improve CAD risk stratification in patients.

Check out the full featured article in Volume 13, Issue 4 of Proteomics – Clinical Applications

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