TMIC’s Global Metabolomics platform integrates complementary technologies to deliver both broad metabolome and lipidome coverage and targeted, high-quality quantification. This unified approach combines:
- HP-CIL LC–MS for high-coverage metabolite profiling with enhanced sensitivity and precision
- Global lipidomics for comprehensive lipid analysis across major lipid classes
- FOCUS targeted assays for flexible, fit-for-purpose quantification of selected metabolites
At the core of this platform, High-Performance Chemical Isotope Labeling (HP-CIL) enables high-performance metabolomics by introducing stable isotope tags to metabolites based on shared functional groups. This enhances ionization efficiency and generates paired signals for accurate relative quantification, enabling robust detection of thousands of metabolites with high reproducibility.
While HP-CIL LC–MS and lipidomics provide broad discovery capabilities, the FOCUS platform complements these technologies by enabling targeted analysis of specific metabolites—particularly those not covered by global methods—and offering multiple levels of quantification, including absolute, semi-quantitative, and relative approaches.
Together, these technologies form a unified Global Metabolomics solution, supporting the full spectrum of metabolomics research—from discovery to targeted validation—and are well suited for applications such as biomarker identification, pathway analysis, and mechanistic studies.
The HP-CIL Metabolomics assay utilizes TMIC’s High-Performance Chemical Isotope Labeling (HP-CIL) technology to deliver both extensive metabolome coverage and highly accurate relative quantification of detected metabolites. By introducing stable isotope tags to metabolites based on shared functional groups, this approach enhances detection sensitivity and enables robust, reproducible quantification across large sample sets.
The Global Lipidomics assay utilizes TMIC's expertise in separations and precision mass spectrometry to deliver extensive coverage of the lipidome, unlocking insights into the biological activity of these critical, but difficult-to-measure biomolecules for disease research, neuroscience, chronic diseases, and more.
The FOCUS Targeted Metabolomics platform provides flexible, high-quality analysis of selected metabolites and lipids tailored to specific research needs. It offers fit-for-purpose quantification, ranging from clinical-grade absolute quantification using isotope-labeled standards to semi-quantitative and relative measurements for comparative studies.
The SHARP (Small-Scale, Highly Accurate, and Reproducible Platform) Metabolomics Assay adapts the comprehensive metabolome coverage and highly accurate relative quantification of the CIL-LC-MS assay to a smaller format—enabling high-sensitivity metabolome profiling for plasma and serum samples as small as 4 µL, and for cell samples containing as few as 5,000 cells.
The Plant Metabolme Assay offers comprehensive analysis of the metabolome of plants, using highly-optimized extraction, separation, and detection methods to ensure the best possible coverage of this complex chemical space. PMA has applications in crop science, environmental analysis,nutrition, and others.
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