Untargeted metabolomics aims to profile the broadest possible range of metabolites in a biological sample without prior knowledge of specific targets. It is an exploratory approach, ideal for discovering novel metabolites, studying metabolic pathways, or identifying biomarkers in disease research. By capturing a wide array of metabolite signals, untargeted metabolomics provides a comprehensive snapshot of the metabolome.
This assay utilizes multidimensional gas chromatography to enable separations and detection of gas-phase molecules that are difficult to detect using liquid chromatography-based methods. This unlocks a host of applications in volatilomics, agricultural and plant sciences, lung and breath-based metabolomic studies, and analysis of environmental exposures.
TMIC has pioneered a method of multi-sample injection capillary electrophoresis which enables extremely high sample throughput metabolomics in clinical and population studies. This service can generate high-precision untargeted data across thousands of samples roughly one order of magnitude faster than classical metabolomics methods.
This assay analyzes a wide range of metabolites in biological samples with no a priori knowledge of sample composition. Using ultra-performance liquid chromatography and Fourier-transform mass spectrometry, untargeted metabolomics is able to deliver high-resolution metabolomic profiles and enable research across biological, medical, and pharmaceitucal domains.
Additionally, TMIC offers global metabolomics analysis where untargeted metabolites are profiled along with a list of targeted metabolites from known metabolic pathways
Targeted + Untargeted
Combine the power of broad detection with precise relative quantification through global metabolomics. Utilizing Chemical Isotope Labeling (CIL), this approach offers comprehensive metabolome coverage while delivering accurate relative quantification of metabolites. Perfect for studies that require discovery and quantification in one streamlined workflow.
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